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Cover Feature: Horseradish Peroxidase Catalyzed Hydrogelation for Biomedical, Biopharmaceutical, and Biofabrication Applications (Chem. Asian J. 24/2017)
Author(s) -
Sakai Shinji,
Nakahata Masaki
Publication year - 2017
Publication title -
chemistry – an asian journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.18
H-Index - 106
eISSN - 1861-471X
pISSN - 1861-4728
DOI - 10.1002/asia.201701489
Subject(s) - biofabrication , horseradish peroxidase , chemistry , hydrogen peroxide , self healing hydrogels , peroxidase , phenol red , combinatorial chemistry , phenol , nanotechnology , organic chemistry , enzyme , materials science , tissue engineering , biomedical engineering , medicine
Gelling together : Horseradish peroxidase catalyzes crosslinking of phenol derivatives using hydrogen peroxide as the oxidant. In the aqueous solution containing polymer‐possessing phenol moieties, enzyme‐mediated crosslinking induces hydrogelation. The hydrogelation proceeds under mild reaction conditions for mammalian cells, at room temperature and neutral pH. The time necessary for hydrogelation, and the mechanical and biological properties of the hydrogels are controllable. Owing to these features, enzymatic hydrogelation has attracted much attention in biomedicine, biopharmaceutics, and biofabrication. More information can be found in the Focus Review by Shinji Sakai and Masaki Nakahata on page 3098 in Issue 24, 2017 (DOI: 10.1002/asia.201701364).