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Metal‐Catalyzed C−H Bond Activation of 5‐Membered Carbocyclic Rings: A Powerful Access to Azulene, Acenaphthylene and Fulvene Derivatives
Author(s) -
Shi Xinzhe,
Sasmal Arpan,
Soulé JeanFrançois,
Doucet Henri
Publication year - 2018
Publication title -
chemistry – an asian journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.18
H-Index - 106
eISSN - 1861-471X
pISSN - 1861-4728
DOI - 10.1002/asia.201701455
Subject(s) - fulvene , acenaphthylene , azulene , chemistry , ring (chemistry) , catalysis , photochemistry , medicinal chemistry , organic chemistry , naphthalene
Azulene, acenaphthylene and fulvene derivatives exhibit important physical properties useful in materials chemistry as well as valuable biological properties. Since about two decades ago, the metal‐catalyzed functionalization of such compounds, via C−H bond activation of their 5‐membered carbocyclic ring, proved to be a very convenient method for the synthesis of a wide variety of azulene, acenaphthylene and fulvene derivatives. For such reactions, there is no need to prefunctionalize the 5‐membered carbocyclic rings. In this review, the progress in the synthesis of azulene, acenaphthylene and fulvene derivatives via metal‐catalyzed C−H bond activation of their 5‐membered carbocyclic ring are summarized.