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Solvent‐Driven Iodine‐Mediated Oxidative Strategies for the Synthesis of Bis(imidazo[1,2‐ a ]pyridin‐3‐yl)sulfanes and Disulfanes
Author(s) -
Shakoor S. M. Abdul,
Agarwal Devesh S.,
Khullar Sadhika,
Mandal Sanjay K.,
Sakhuja Rajeev
Publication year - 2017
Publication title -
chemistry – an asian journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.18
H-Index - 106
eISSN - 1861-471X
pISSN - 1861-4728
DOI - 10.1002/asia.201701274
Subject(s) - iodine , chemistry , sulfur , oxidative phosphorylation , chloroform , solvent , acetic acid , combinatorial chemistry , sulfide , organic chemistry , medicinal chemistry , biochemistry
Two efficient iodine‐mediated strategies, which are economical and one‐pot, are described to access bis(imidazo[1,2‐ a ]pyridin‐3‐yl)sulfanes and bis(imidazo[1,2‐ a ]pyridin‐3‐yl)disulfanes in chloroform and acetic acid, respectively, by a direct oxidative homocoupling of imidazo‐heterocycles using inexpensive sodium sulfide as a sulfur source. These strategies are scalable, and an array of substrates delivered their corresponding stable sulfur‐bridged imidazo‐heterocycles in excellent yields.