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Copper‐Catalyzed Alkynylboration of Alkenes with Diboron Reagents and Bromoalkynes
Author(s) -
Gong TianJun,
Yu ShangHai,
Li Kuan,
Su Wei,
Lu Xi,
Xiao Bin,
Fu Yao
Publication year - 2017
Publication title -
chemistry – an asian journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.18
H-Index - 106
eISSN - 1861-471X
pISSN - 1861-4728
DOI - 10.1002/asia.201701176
Subject(s) - reagent , chemistry , functional group , combinatorial chemistry , catalysis , copper , selectivity , substrate (aquarium) , molecule , compatibility (geochemistry) , organic chemistry , materials science , oceanography , polymer , composite material , geology
An efficient method for the synthesis of homopropargylboronates by copper‐catalyzed alkynylboration of alkenes with diboron reagents and bromoalkynes has been developed. The alkynylboration reaction features high selectivity and efficiency, mild reaction conditions, wide substrate scope, and functional‐group compatibility, and is a highly attractive complement to existing methods for the synthesis of homopropargylboronates. Both the boryl and alkynyl groups are good potential functional groups for the subsequent manipulations that provide access to a variety of important molecule structures.