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Cover Feature: Robust Acenaphthoimidazolylidene Palladacycles: Highly Efficient Catalysts for the Amination of N‐Heteroaryl Chlorides (Chem. Asian J. 18/2017)
Author(s) -
Deng Qinyue,
Zhang Yang,
Zhu Haibo,
Tu Tao
Publication year - 2017
Publication title -
chemistry – an asian journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.18
H-Index - 106
eISSN - 1861-471X
pISSN - 1861-4728
DOI - 10.1002/asia.201701055
Subject(s) - amination , catalysis , combinatorial chemistry , chemistry , rosiglitazone , cover (algebra) , carbene , organic chemistry , engineering , biochemistry , mechanical engineering , receptor
The perfect match : Challenging and selective amination of N ‐ heteroaryl chlorides by diverse primary and secondary amines has been successfully realized by using robust and congested N‐heterocyclic carbene palladacycles as catalysts. Furthermore, the coupling protocol is readily extended to synthesize rosiglitazone, a clinical drug for diabetes mellitus, highlighting its potential pharmaceutical feasibility. More information can be found in the Communication by Tao Tu et al. on page 2364 in Issue 18, 2017 (DOI: 10.1002/asia.201700877).