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Efficient [Cu(NHC)]‐Catalyzed Multicomponent Synthesis of Pyrroles
Author(s) -
Dang Tuan Thanh,
Seayad Abdul Majeed
Publication year - 2017
Publication title -
chemistry – an asian journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.18
H-Index - 106
eISSN - 1861-471X
pISSN - 1861-4728
DOI - 10.1002/asia.201701045
Subject(s) - ketone , catalysis , component (thermodynamics) , amine gas treating , chemistry , pyrrole , coupling reaction , alcohol , diol , organic chemistry , primary (astronomy) , combinatorial chemistry , physics , thermodynamics , astronomy
Efficient [Cu(NHC)]‐catalyzed syntheses of pyrroles via two and three‐component coupling methods are described. Various 1,2‐, 1,2,3‐, 1,2,3,5‐ and fully substituted pyrroles were readily accessible through a suitable choice of ketone, primary amine and diol in a three‐component reaction. The N‐unsubstituted pyrrole formation is also feasible through a two‐component reaction involving a β‐amino alcohol and a ketone.
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