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A Facile Route to Ortho ‐Hydroxyanilnes through an Ir III ‐Catalyzed Direct C−H Amidation of 2‐Phenoxypyridines
Author(s) -
Wang Lianhui,
Yang Zi,
Yang Mengqi,
Tian Miaodou,
Kuai Changsheng,
Cui Xiuling
Publication year - 2017
Publication title -
chemistry – an asian journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.18
H-Index - 106
eISSN - 1861-471X
pISSN - 1861-4728
DOI - 10.1002/asia.201701028
Subject(s) - regioselectivity , moiety , catalysis , sulfonyl , chemistry , functional group , combinatorial chemistry , medicinal chemistry , organic chemistry , alkyl , polymer
A highly efficient and regioselective Ir III ‐catalyzed C−H amidation of 2‐phenoxypyridines has been developed by using sulfonyl azides as an amino source. The amidated products were provided in good‐to‐excellent yields with broad functional‐group tolerance. Furthermore, the 2‐pyridyl moiety in the amidated products could be readily removed, thus offering an efficient route to synthetically useful ortho ‐hydroxyanilnes, which are important building blocks in organic synthesis.