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Synthesis and Configuration of Neomaclafungin A
Author(s) -
Zhu Shijun,
Wu Yikang
Publication year - 2017
Publication title -
chemistry – an asian journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.18
H-Index - 106
eISSN - 1861-471X
pISSN - 1861-4728
DOI - 10.1002/asia.201700950
Subject(s) - diastereomer , enantioselective synthesis , absolute configuration , task (project management) , key (lock) , total synthesis , natural product , product (mathematics) , computer science , stereochemistry , chemistry , mathematics , engineering , organic chemistry , geometry , computer security , catalysis , systems engineering
The relative and absolute configuration of neomaclafungins were impossible to establish by spectroscopic analyses alone because of the lack of exploitable 1 H‐ 1 H couplings and nOes between the upper and the lower subunits. This very difficult task now is finally completed by an enantioselective total synthesis of neomaclafungin A (revised) and its diastereomer (reported). The results also provided a key reference for the complete structures for other neomaclafungins and the long‐known closely related natural product maclafungin.