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Stereogenic‐Only‐at‐Metal Asymmetric Catalysts
Author(s) -
Zhang Lilu,
Meggers Eric
Publication year - 2017
Publication title -
chemistry – an asian journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.18
H-Index - 106
eISSN - 1861-471X
pISSN - 1861-4728
DOI - 10.1002/asia.201700739
Subject(s) - stereocenter , catalysis , metal , chirality (physics) , ligand (biochemistry) , asymmetric induction , materials science , enantioselective synthesis , chemistry , combinatorial chemistry , organic chemistry , physics , biochemistry , chiral symmetry breaking , receptor , quantum mechanics , quark , nambu–jona lasinio model
Chirality is an essential feature of asymmetric catalysts. This review summarizes asymmetric catalysts that derive their chirality exclusively from stereogenic metal centers. Reported chiral‐at‐metal catalysts can be divided into two classes, namely, inert metal complexes, in which the metal fulfills a purely structural role, so catalysis is mediated entirely through the ligand sphere, and reactive metal complexes. The latter are particularly appealing because structural simplicity (only achiral ligands) is combined with the prospect of particularly effective asymmetric induction (direct contact of the substrate with the chiral metal center). Challenges and solutions for the design of such reactive stereogenic‐only‐at‐metal asymmetric catalysts are discussed.