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Cover Picture: Enhanced Fluorescence Imaging and Photodynamic Cancer Therapy Using Hollow Mesoporous Nanocontainers (Chem. Asian J. 14/2017)
Author(s) -
Hong Suk ho,
Kim Hyunjin,
Choi Yongdoo
Publication year - 2017
Publication title -
chemistry – an asian journal
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.18
H-Index - 106
eISSN - 1861-471X
pISSN - 1861-4728
DOI - 10.1002/asia.201700709
Subject(s) - photodynamic therapy , mesoporous silica , materials science , cancer therapy , mesoporous material , fluorescence , cover (algebra) , nanotechnology , cancer , medicine , chemistry , optics , organic chemistry , engineering , physics , mechanical engineering , catalysis
Smart silica nanobombs : An “off‐on” type of photodynamic therapy agent was developed from hollow mesoporous silica nanoparticles (HMSNPs), to enable not only an enhanced delivery of photosensitizers to cancer cells, but also a selective turn‐on of fluorescence signal and phototoxicity inside the cancer cells. Both the fluorescence and singlet‐oxygen generation of the photosensitizer were quenched (i.e. OFF) when loaded inside the HMSNPs. After internalization of HMSNPs into cancer cells, the photosensitizer was released from the HMSNPs, thereby regaining fluorescence and phototoxicity (i.e. ON). More information can be found in the Communication by Yongdoo Choi et al. on page 1700 in Issue 14, 2017 (DOI: 10.1002/asia.201700371).