Premium
Thermosensitive Triterpenoid‐Appended Polymers with Broad Temperature Tunability Regulated by Host–Guest Chemistry
Author(s) -
Hao Jie,
Gao Yuxia,
Li Ying,
Yan Qiang,
Hu Jun,
Ju Yong
Publication year - 2017
Publication title -
chemistry – an asian journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.18
H-Index - 106
eISSN - 1861-471X
pISSN - 1861-4728
DOI - 10.1002/asia.201700581
Subject(s) - lower critical solution temperature , methacrylate , polymer , aqueous solution , copolymer , chemistry , chemical engineering , polymer chemistry , thermoresponsive polymers in chromatography , aqueous medium , materials science , organic chemistry , phase (matter) , reversed phase chromatography , engineering
Thermoresponsive water‐soluble polymers are of great importance since they typically show a lower critical solution temperature (LCST) in aqueous media. In this research, the LCST change in broad temperature ranges of copolymers composed of natural glycyrrhetinic acid (GA)‐based methacrylate and N , N′ ‐dimethylacrylamides (DMAs) was investigated as a function of the concentration and the content of GA pendants. By complexation of GA pendants with β‐cyclodextrin (β‐CD), a side‐chain polypseudorotaxane was obtained, which exhibited a significant increase in the LCST of copolymers. Moreover, the precisely reversible control of the LCST behavior was realized through adding a competing guest molecule, sodium 1‐admantylcarboxylate. This work illustrates a simple and effective approach to endow water‐soluble polymers with broad temperature tunability and helps us further understand the effect of a biocompatible host–guest complementary β‐CD/GA pair on the thermoresponsive process.