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Asymmetric Total Syntheses of (−)‐α‐Lycorane, (−)‐Zephyranthine, and Formal Synthesis of (+)‐Clivonine
Author(s) -
Chen YongJian,
Cai SenLin,
Wang ChuanChuan,
Cheng JinDuo,
Kramer Søren,
Sun XingWen
Publication year - 2017
Publication title -
chemistry – an asian journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.18
H-Index - 106
eISSN - 1861-471X
pISSN - 1861-4728
DOI - 10.1002/asia.201700555
Subject(s) - formal synthesis , total synthesis , imine , enantioselective synthesis , chemistry , stereochemistry , combinatorial chemistry , catalysis , organic chemistry
An asymmetric route to (−)‐α‐lycorane and (−)‐zephyranthine, and a formal total synthesis of (+)‐clivonine were achieved. A pivotal intermediate, which serves as a potent precursor for the divergent syntheses of these natural products, was accessed by a diastereoselective Pd‐catalyzed cinnamylation of an N ‐ tert ‐butanesulfinyl imine.
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