MnO 2 ‐Promoted Oxidative Radical Sulfonylation of Haloalkynes with Sulfonyl Hydrazides: C(sp)–S Bond Formation towards Alkynyl Sulfones | Zendy

Chen Pengquan | Zendy; Zhu Chuanle | Zendy; Zhu Rui | Zendy; Wu Wanqing | Zendy; Jiang Huanfeng | Zendy

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MnO 2 ‐Promoted Oxidative Radical Sulfonylation of Haloalkynes with Sulfonyl Hydrazides: C(sp)–S Bond Formation towards Alkynyl Sulfones

Author(s) -

Chen Pengquan,

Zhu Chuanle,

Zhu Rui,

Wu Wanqing,

Jiang Huanfeng

Publication year - 2017

Publication title -

chemistry – an asian journal

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.18

H-Index - 106

eISSN - 1861-471X

pISSN - 1861-4728

DOI - 10.1002/asia.201700550

Subject(s) - sulfonyl , chemistry , oxidative phosphorylation , medicinal chemistry , catalysis , oxidative coupling of methane , polymer chemistry , organic chemistry , biochemistry , alkyl

A catalyst‐free oxidative radical sulfonylation of haloalkynes with sulfonyl hydrazides is reported. It represents an example of C(sp)−S bond formation using sulfonyl hydrazides as sulfonyl radical sources. Various alkynyl sulfones were synthesized in moderate to good yields. Having MnO 2 as the oxidant is very critical for this transformation. Remarkably, the self‐coupling reaction of haloalkynes through C(sp)−C(sp) bond formation is significantly inhibited under the standard reaction conditions.

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