Premium
Cover Picture: Enzymatic Synthesis of 7′,5′‐Bicyclo‐DNA Oligonucleotides (Chem. Asian J. 12/2017)
Author(s) -
Diafa Stella,
Evéquoz Damien,
Leumann Christian J.,
Hollenstein Marcel
Publication year - 2017
Publication title -
chemistry – an asian journal
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.18
H-Index - 106
eISSN - 1861-471X
pISSN - 1861-4728
DOI - 10.1002/asia.201700532
Subject(s) - oligonucleotide , dna , bicyclic molecule , dna polymerase , dna synthesis , nucleoside , nucleotide , enzyme , synthetic biology , biochemistry , chemistry , dna sequencing , biology , combinatorial chemistry , stereochemistry , computational biology , gene
Going bicyclo ! A nucleoside triphosphate analogue based on the bicyclo‐DNA architecture (7’,5’‐bc‐TTP) was synthesized, and its potential to serve for the generation of new xenonucleic acids (XNAs) was assessed. When used with the Therminator DNA polymerase, up to seven modified 7’,5’‐bc‐nucleotides could be incorporated into DNA. In addition, this scaffold also supports XNA‐dependent DNA synthesis as well as potentially XNA‐dependent XNA synthesis, and thus represents a candidate for the generation of novel synthetic genetic polymers. More information can be found in the Communication by Christian Leumann, Marcel Hollenstein et al. on page 1347 in Issue 12, 2017 (DOI: 10.1002/asia.201700374).