Structural Elucidation of Trace Amounts of Volatile Compounds Using the Crystalline Sponge Method

Volatile organic compounds are widely present as scents and odors in our daily lives and are readily found in a variety of natural extracts. Because these compounds are highly volatile and usually available only in minute quantities, little attention has been paid to X‐ray diffraction as a technique for their structure determination. Here, we show that the structures of volatile organic compounds are easily elucidated using minute quantities of the compounds and the crystalline sponge method. The compound vapors can be directly absorbed into the sponge crystals, or alternatively, preparative gas chromatography can be used to separate the desired compound from a natural mixture.