Short Syntheses of 4‐Deoxycarbazomycin B, Sorazolon E, and (+)‐Sorazolon E2 | Zendy

Sako Makoto | Zendy; Ichinose Kazuya | Zendy; Takizawa Shinobu | Zendy; Sasai Hiroaki | Zendy

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Short Syntheses of 4‐Deoxycarbazomycin B, Sorazolon E, and (+)‐Sorazolon E2

Author(s) -

Sako Makoto,

Ichinose Kazuya,

Takizawa Shinobu,

Sasai Hiroaki

Publication year - 2017

Publication title -

chemistry – an asian journal

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.18

H-Index - 106

eISSN - 1861-471X

pISSN - 1861-4728

DOI - 10.1002/asia.201700471

Subject(s) - intramolecular force , enantioselective synthesis , cyclohexanone , aromatization , oxidative coupling of methane , chemistry , vanadium , condensation , oxidative phosphorylation , stereochemistry , medicinal chemistry , catalysis , combinatorial chemistry , organic chemistry , biochemistry , physics , thermodynamics

Short syntheses of 4‐deoxycarbazomycin B and sorazolon E were established through the condensation of cyclohexanone and commercially available 4‐methoxy‐2,3‐dimethylaniline, followed by Pd II ‐catalyzed dehydrogenative aromatization/intramolecular C−C bond coupling and deprotection. A chiral dinuclear vanadium complex ( R a ,S,S )‐ 6 mediated the enantioselective oxidative coupling of sorazolon E, affording (+)‐sorazolon E2 in good enantioselectivity.

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