Premium
Enhanced Fluorescence Imaging and Photodynamic Cancer Therapy Using Hollow Mesoporous Nanocontainers
Author(s) -
Hong Suk ho,
Kim Hyunjin,
Choi Yongdoo
Publication year - 2017
Publication title -
chemistry – an asian journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.18
H-Index - 106
eISSN - 1861-471X
pISSN - 1861-4728
DOI - 10.1002/asia.201700371
Subject(s) - photodynamic therapy , photosensitizer , singlet oxygen , mesoporous silica , fluorescence , materials science , nanotechnology , fluorescence lifetime imaging microscopy , cancer therapy , cancer cell , nanoparticle , mesoporous material , photochemistry , chemistry , cancer , optics , medicine , oxygen , catalysis , organic chemistry , physics
Here we show that “off‐on” type of photodynamic therapy agents could be developed using hollow mesoporous silica nanoparticles (HMSNPs), which can be used not only for enhancing delivery of photosensitizers to cancer cells but also for enabling switchable optical properties of the photosensitizers. Fluorescence and singlet oxygen generation of the photosensitizer‐loaded HMSNP are turned off in its native state. In vitro cell studies showed that this HMSNP‐based “off‐on” agent may have potential utility in selective fluorescence detection and photodynamic therapy of cancers.