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A Scalable and Versatile Synthesis of Oxime‐Based Hormone Dimers and Gels for Sustained Release
Author(s) -
Bennett Christopher W.,
Collins Joe,
Xiao Zeyun,
Klinger Daniel,
Connal Luke A.
Publication year - 2017
Publication title -
chemistry – an asian journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.18
H-Index - 106
eISSN - 1861-471X
pISSN - 1861-4728
DOI - 10.1002/asia.201700288
Subject(s) - oxime , linker , steroid , hormone , chemistry , hydrolysis , click chemistry , combinatorial chemistry , steroid hormone , organic chemistry , biochemistry , computer science , operating system
Well‐defined steroid hormone dimers and organogels were produced via a facile and scalable synthesis using oxime click chemistry. The versatile synthetic procedure extends to a wide range of hormones and linker groups exemplified here through the synthesis of cortisol‐ and progesterone‐dimers linked via hydrophobic, hydrophilic or functional groups. This method was also extended to the synthesis of cortisone‐based organogels. Owing to the dynamic nature of the oxime bond, the hormone‐based materials are degradable via acidic hydrolysis and transoximination representing new materials for the controlled release of steroid hormones.