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Cover Picture: Stimulus‐Responsive Short Peptide Nanogels for Controlled Intracellular Drug Release and for Overcoming Tumor Resistance (Chem. Asian J. 7/2017)
Author(s) -
Lyu Linna,
Liu Fang,
Wang Xiaoyong,
Hu Ming,
Mu Jing,
Cheong Haolun,
Liu Gang,
Xing Bengang
Publication year - 2017
Publication title -
chemistry – an asian journal
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.18
H-Index - 106
eISSN - 1861-471X
pISSN - 1861-4728
DOI - 10.1002/asia.201700163
Subject(s) - intracellular , peptide , cover (algebra) , chemistry , drug delivery , stimulus (psychology) , drug resistance , biophysics , pharmacology , cancer research , biochemistry , biology , psychology , psychotherapist , microbiology and biotechnology , engineering , organic chemistry , mechanical engineering
Overcoming resistance : Multidrug resistance (MDR) remains a major problem for effective chemotherapy. In this study, a smart stimulus‐responsive self‐assembled system (PD/VER nanogel), formed from a short peptide‐Dox prodrug (PD) and the P‐glycoprotein inhibitor Verapamil (VER), was successfully developed for overcoming MDR. Such inhibitor‐encapsulated nanogels could greatly enhance the accumulation of drugs in resistant cancer cells, thereby effectively reversing tumor resistance. More information can be found in the Full Paper by Fang Liu, Bengang Xing et al. on page 744 in Issue 7, 2017 (DOI: 10.1002/asia.201601704).