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Metal‐Ion‐Mediated Supramolecular Assembly of C 3 ‐Peptides
Author(s) -
Wang Jun,
Shao Feng,
Li Wen,
Yan Jiatao,
Liu Kun,
Tao Pei,
Masuda Toshio,
Zhang Afang
Publication year - 2017
Publication title -
chemistry – an asian journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.18
H-Index - 106
eISSN - 1861-471X
pISSN - 1861-4728
DOI - 10.1002/asia.201601721
Subject(s) - supramolecular chemistry , supramolecular chirality , hydrogen bond , chirality (physics) , metal ions in aqueous solution , crystallography , metal , tetrapeptide , chemistry , intermolecular force , supramolecular assembly , molecule , peptide , self assembly , stereochemistry , materials science , crystal structure , organic chemistry , biochemistry , nambu–jona lasinio model , chiral symmetry breaking , physics , quantum mechanics , quark
An investigation on a supramolecular assembly of C 3 ‐molecules benzene‐1,3,5‐tricarboxamides carrying tetrapeptide Gly‐Ala‐Gly‐Ala pendants promoted by hydrogen bonding and metal ion coordination is described. A Gly‐Ala peptide sequence was selected as it is the most abundant repeating unit in silkworm silk, and known to form β‐sheets through efficient intermolecular hydrogen bonds. These C 3 ‐peptides formed long helical fibers in solvents mainly owing to strong hydrogen bonding. However, in the presence of divalent metal ions, chirality of these helical fibers was enhanced through metal coordination and could be transformed into nanospheres with an excess amount of the ions. Different metal ions show different tendencies to mediate the supramolecular chirality, which can even be inverted according to coordination differences.