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Cover Picture: Rhodium‐Catalyzed Regioselective C7‐Olefination of Indazoles Using an N‐Amide Directing Group (Chem. Asian J. 3/2017)
Author(s) -
Guo Lei,
Chen Yanyu,
Zhang Rong,
Peng Qiujun,
Xu Lanting,
Pan Xianhua
Publication year - 2017
Publication title -
chemistry – an asian journal
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.18
H-Index - 106
eISSN - 1861-471X
pISSN - 1861-4728
DOI - 10.1002/asia.201601687
Subject(s) - rhodium , amide , regioselectivity , catalysis , group (periodic table) , chemistry , cover (algebra) , stereochemistry , combinatorial chemistry , organic chemistry , engineering , mechanical engineering
A rhodium‐catalyzed regioselective C7‐functionalization of indazoles without any substituent at the C3‐position has been achieved. The removable N , N ‐diisopropylcarbamoyl directing group proved crucial for both C7‐regioselecivity and conversion. Good to excellent yields were observed with acrylates, vinyl phenyl sulfones, and electron‐neutral olefins (styrenes). The reaction could conveniently be scaled up to a gram scale, thus highlighting the robustness and practicality of this transformation. More information can be found in the Communication by Xianhua Pan, Lanting Xu et al. on page 289 in Issue 3, 2017 (DOI: 10.1002/asia.201601456).