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Synthesis of 1‐Difluoroalkylated Isoquinolines via Palladium‐Catalyzed Radical Cascade Difluoroalkylation–Cyclization of Vinyl Isocyanides with Bromodifluoroacetic Derivatives
Author(s) -
Liu Yingle,
Zhang Ke,
Jiang Weidong,
Yang Yi,
Jiang Yan,
Liu Xiaoqiang,
Xie Ying,
Wu Jincai,
Cai Junjie,
Xu XiuHua
Publication year - 2017
Publication title -
chemistry – an asian journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.18
H-Index - 106
eISSN - 1861-471X
pISSN - 1861-4728
DOI - 10.1002/asia.201601645
Subject(s) - palladium , catalysis , chemistry , cascade , radical cyclization , combinatorial chemistry , organic chemistry , cascade reaction , chromatography
A general method was developed for the synthesis of 1‐difluoroalkyl isoquinolines via the palladium‐catalyzed radical cascade difluoroalkylation–cyclization of vinyl isocyanides with bromodifluoroacetic derivatives. The difluoroalkylated cyclization products were readily converted to various other valuable gem ‐difluoro‐containing compounds.