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Nickel‐Catalyzed Facile [2+2+2] Cyclotrimerization of Unactivated Internal Alkynes to Polysubstituted Benzenes
Author(s) -
Xue Fei,
Loh Ying Kai,
Song Xiaolu,
Teo Wei Jie,
Chua J. Y. Darrence,
Zhao Jin,
Hor T. S. Andy
Publication year - 2017
Publication title -
chemistry – an asian journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.18
H-Index - 106
eISSN - 1861-471X
pISSN - 1861-4728
DOI - 10.1002/asia.201601469
Subject(s) - catalysis , regioselectivity , reagent , chemistry , nickel , salt (chemistry) , grignard reagent , combinatorial chemistry , organic chemistry
Abstract A catalytic [2+2+2] cyclotrimerization of unactivated internal alkynes providing cyclotrimerization products in excellent yields with high regioselectivity is described. The transformation is accomplished by using a simple catalytic mixture comprising Ni(acac) 2 , an imidazolium salt and a Grignard reagent at room temperature or 60 °C for 20 min or 1 h.