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Rhodium‐Catalyzed Regioselective C7‐Olefination of Indazoles Using an N‐Amide Directing Group
Author(s) -
Guo Lei,
Chen Yanyu,
Zhang Rong,
Peng Qiujun,
Xu Lanting,
Pan Xianhua
Publication year - 2017
Publication title -
chemistry – an asian journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.18
H-Index - 106
eISSN - 1861-471X
pISSN - 1861-4728
DOI - 10.1002/asia.201601456
Subject(s) - regioselectivity , rhodium , indazole , amide , catalysis , functional group , group (periodic table) , substrate (aquarium) , chemistry , combinatorial chemistry , stereochemistry , organic chemistry , biology , ecology , polymer
A rhodium‐catalyzed regioselective C−H olefination of indazole is described. This protocol relies on the use of an efficient and removable N , N ‐diisopropylcarbamoyl directing group, which offers facile access to C7‐olefinated indazoles with high regioselectivity, ample substrate scope and broad functional group tolerance.