Rhodium‐Catalyzed Regioselective C7‐Olefination of Indazoles Using an N‐Amide Directing Group | Zendy

Guo Lei | Zendy; Chen Yanyu | Zendy; Zhang Rong | Zendy; Peng Qiujun | Zendy; Xu Lanting | Zendy; Pan Xianhua | Zendy

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Rhodium‐Catalyzed Regioselective C7‐Olefination of Indazoles Using an N‐Amide Directing Group

Author(s) -

Guo Lei,

Chen Yanyu,

Zhang Rong,

Peng Qiujun,

Xu Lanting,

Pan Xianhua

Publication year - 2017

Publication title -

chemistry – an asian journal

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.18

H-Index - 106

eISSN - 1861-471X

pISSN - 1861-4728

DOI - 10.1002/asia.201601456

Subject(s) - regioselectivity , rhodium , indazole , amide , catalysis , functional group , group (periodic table) , substrate (aquarium) , chemistry , combinatorial chemistry , stereochemistry , organic chemistry , biology , ecology , polymer

A rhodium‐catalyzed regioselective C−H olefination of indazole is described. This protocol relies on the use of an efficient and removable N , N ‐diisopropylcarbamoyl directing group, which offers facile access to C7‐olefinated indazoles with high regioselectivity, ample substrate scope and broad functional group tolerance.

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