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Chloroacetate Promotes and Participates in the Oxidative Annulation of Pyridines/Isoquinoline by Using Oxygen as the Oxidant
Author(s) -
Yue Yuanyuan,
Sun Yangyang,
Zhao Shufang,
Yan Xuyang,
Li Rong,
Shi Yaru,
Zhuo Kelei,
Liu Jianming
Publication year - 2016
Publication title -
chemistry – an asian journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.18
H-Index - 106
eISSN - 1861-471X
pISSN - 1861-4728
DOI - 10.1002/asia.201601233
Subject(s) - annulation , isoquinoline , chemistry , oxidative phosphorylation , oxygen , organic chemistry , catalysis , biochemistry
The aerobic oxidative annulation of chalcones, pyridines/isoquinoline and ethyl chloroacetate to indolizines was achieved by cascade reaction. Various functional groups on chalcones were tolerated. And different pyridines derivatives could also be suitable substrates. Ethyl chloroacetate is an essential component in participating of the oxidative annulation process. Overall, this protocol is very practical and efficient by using molecular oxygen as oxidant with high selectivity for the annulation product.