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Self‐Assembly of Amphiphilic Drug–Dye Conjugates into Nanoparticles for Imaging and Chemotherapy
Author(s) -
Sun Tingting,
Lin Wenhai,
Zhang Wei,
Xie Zhigang
Publication year - 2016
Publication title -
chemistry – an asian journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.18
H-Index - 106
eISSN - 1861-471X
pISSN - 1861-4728
DOI - 10.1002/asia.201601206
Subject(s) - amphiphile , conjugate , cytotoxicity , drug delivery , drug , nanoparticle , combinatorial chemistry , confocal microscopy , materials science , chemistry , aqueous solution , nanotechnology , drug carrier , biophysics , organic chemistry , copolymer , pharmacology , biochemistry , in vitro , medicine , polymer , mathematical analysis , mathematics , microbiology and biotechnology , biology
An amphiphilic drug–dye conjugate ( PTX‐Pt‐BDP ) was designed and synthesized with a platinum compound as the hydrophilic head. The precursor of PTX‐Pt‐BDP was obtained under mild conditions by means of a three‐component Passerini reaction. PTX‐Pt‐BDP could self‐assemble into nanoparticles ( PTX‐Pt‐BDP NPs) in aqueous solution via a nanoprecipitation method. The obtained nanoparticles exhibited favorable structural stability in both water and physiological environment. PTX‐Pt‐BDP NPs could be endocytosed by cancer cells as revealed by confocal laser scanning microscopy and exert potent cytotoxicity. This work highlights the potential of nanomedicines from amphiphilic drug–dye conjugates for cancer cell imaging and chemotherapy.