Premium
Rhodium/Silver‐Cocatalyzed Transannulation of N ‐Sulfonyl‐1,2,3‐triazoles with Vinyl Azides: Divergent Synthesis of Pyrroles and 2 H ‐Pyrazines
Author(s) -
Zhang Lin,
Sun Ge,
Bi Xihe
Publication year - 2016
Publication title -
chemistry – an asian journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.18
H-Index - 106
eISSN - 1861-471X
pISSN - 1861-4728
DOI - 10.1002/asia.201601164
Subject(s) - sulfonyl , chemistry , rhodium , reaction conditions , catalysis , combinatorial chemistry , substrate (aquarium) , functional group , azide , organic chemistry , polymer chemistry , alkyl , polymer , oceanography , geology
The first cyclization reaction between vinyl azides and N ‐sulfonyl‐1,2,3‐triazoles is reported. A Rh/Ag binary metal catalyst system proved to be necessary for the successful cyclization. By varying the structure of vinyl azides, such reaction allows the divergent synthesis of pyrroles and 2 H ‐pyrazines. The cyclization reactions feature a broad substrate scope, good functional group tolerance, high reaction efficiency, and good to high product yields.