Chemoselective, Substrate‐directed Fluorination of Functionalized Cyclopentane β‐Amino Acids

This work describes a substrate‐directed fluorination of some highly functionalized cyclopentane derivatives. The cyclic products incorporating CH 2 F or CHF 2 moieties in their structure have been synthesized from diexo ‐ or diendo ‐norbornene β‐amino acids following a stereocontrolled strategy. The synthetic study was based on an oxidative transformation of the ring carbon–carbon double bond of the norbornene β‐amino acids, followed by transformation of the resulted „ all cis “ and „ trans “ diformyl intermediates by fluorination with „chemodifferentiation“.