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Biomineralization of Versatile CuS/Gd 2 O 3 Hybrid Nanoparticles for MR Imaging and Antitumor Photothermal Chemotherapy
Author(s) -
Zhao HuaiXin,
Wang Hong,
Zou Quan,
Sun ShaoKai,
Yu Chunshui,
Zhang Xuejun,
Fu YanYan
Publication year - 2016
Publication title -
chemistry – an asian journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.18
H-Index - 106
eISSN - 1861-471X
pISSN - 1861-4728
DOI - 10.1002/asia.201600920
Subject(s) - photothermal therapy , in vivo , nanoparticle , bovine serum albumin , materials science , biomineralization , drug delivery , nanotechnology , in vitro , conjugated system , biophysics , chemistry , chemical engineering , polymer , biochemistry , microbiology and biotechnology , engineering , biology , composite material
The versatile application of nanoparticles in integrating imaging and therapy has aroused extensive research interest in precision medicine. Of the various nanoparticles that have been studied, CuS has shown great potential in the construction of multifunctional agents, owing to its excellent photothermal heating properties. Herein, we report a facile one‐pot biomineralization approach for the preparation of versatile bovine‐serum‐albumin‐conjugated CuS/Gd 2 O 3 hybrid nanoparticles (BSA−CuS/Gd 2 O 3 HNPs), which simultaneously possessed strong longitudinal relaxivity, an outstanding photothermal effect, high drug‐loading capacity, and pH/temperature‐responsive drug release. The versatile nanoparticles were used for magnetic resonance imaging (MRI) and antitumor photothermal chemotherapy, both in vitro and in vivo. In vivo MRI showed that the BSA−CuS/Gd 2 O 3 HNPs had a long circulation time and effective passive tumor‐uptake ability. More importantly, combined in vitro and in vivo therapy demonstrated that drug‐loaded BSA−CuS/Gd 2 O 3 HNPs offered outstanding synergistic therapeutic efficacy for tumor inhibition.