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Oxidative β‐Csp 3 −H Functionalization of t BuOH: A Selective Radical/Radical Cross‐Coupling Access to β‐Hydroxy Thioethers
Author(s) -
Li Yuxiu,
Liu Dong,
Liu Chao,
Lei Aiwen
Publication year - 2016
Publication title -
chemistry – an asian journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.18
H-Index - 106
eISSN - 1861-471X
pISSN - 1861-4728
DOI - 10.1002/asia.201600800
Subject(s) - surface modification , chemistry , oxidative phosphorylation , radical , coupling (piping) , polymer chemistry , photochemistry , materials science , organic chemistry , biochemistry , metallurgy
An oxidative β‐Csp 3 −H functionalization of tert ‐butanol ( t BuOH) for the construction of C−S bonds through an iodine‐catalyzed Csp 3 −H/S−H coupling was successfully achieved. Different kinds of mercaptans were shown to be good coupling partners, affording the desired products in good yields. This protocol not only offers a novel method for the synthesis of β‐hydroxy thioethers, but also provides an effective strategy for selective radical/radical cross‐coupling.