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Boronate Affinity–Molecularly Imprinted Biocompatible Probe: An Alternative for Specific Glucose Monitoring
Author(s) -
Chen Guosheng,
Qiu Junlang,
Fang Xu'an,
Xu Jianqiao,
Cai Siying,
Chen Qing,
Liu Yan,
Zhu Fang,
Ouyang Gangfeng
Publication year - 2016
Publication title -
chemistry – an asian journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.18
H-Index - 106
eISSN - 1861-471X
pISSN - 1861-4728
DOI - 10.1002/asia.201600797
Subject(s) - boronic acid , biocompatible material , molecularly imprinted polymer , chemistry , in vivo , molecular imprinting , nanotechnology , continuous glucose monitoring , polymer , combinatorial chemistry , materials science , biochemistry , organic chemistry , selectivity , biomedical engineering , catalysis , medicine , microbiology and biotechnology , glycemic , insulin , biology , endocrinology
Abstract A biocompatible probe for specific glucose recognition is based on photoinitiated boronate affinity–molecular imprinted polymers (BA‐MIPs). The unique pre‐self‐assembly between glucose and boronic acids creates glucose‐specific memory cavities in the BA‐MIPs coating. As a result, the binding constant toward glucose was enhanced by three orders of magnitude. The BA‐MIPs probe was applied to glucose determination in serum and urine and implanted into plant tissues for low‐destructive and long‐term in vivo continuous glucose monitoring.