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Amphiphilic Ditopic Bis‐Aqua Gd‐AAZTA‐like Complexes Enhance Relaxivity of Lipidic MRI Nanoprobes
Author(s) -
Gambino Giuseppe,
Tei Lorenzo,
Carniato Fabio,
Botta Mauro
Publication year - 2016
Publication title -
chemistry – an asian journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.18
H-Index - 106
eISSN - 1861-471X
pISSN - 1861-4728
DOI - 10.1002/asia.201600669
Subject(s) - amphiphile , chemistry , materials science , crystallography , nuclear chemistry , organic chemistry , copolymer , polymer
Two amphiphilic mono‐ and dimeric GdAAZTA‐like chelates composed of stable bis‐aquo Gd III complexes ( q =2) linked to one (for the monomer) or two dodecyl aliphatic chains (for the dimer) were synthesized. Both chelates showed high relaxivity when incorporated into the lipid bilayer of liposomes or after interaction with human serum albumin (HSA). The ditopic complex shows a significantly decreased internal motion relative to the monomeric complex, associated with an enhanced relaxivity ( r 1 ≈60 m m −1 s −1 , at 30 MHz and 310 K). The presence of two metal‐bound water molecules in fast exchange and the restricted rotational freedom make the relaxivity of this system the highest measured for paramagnetic liposomes.