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DNA Triplexes‐Guided Assembly of G‐Quadruplexes for Constructing Label‐free Fluorescent Logic Gates
Author(s) -
Xu Lijun,
Hong Shanni,
Shen Xiaoqiang,
Zhou Lu,
Wang Jine,
Zhang Jianye,
Pei Renjun
Publication year - 2016
Publication title -
chemistry – an asian journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.18
H-Index - 106
eISSN - 1861-471X
pISSN - 1861-4728
DOI - 10.1002/asia.201600626
Subject(s) - fluorescence , dna , computer science , logic gate , g quadruplex , chemistry , computational biology , combinatorial chemistry , biology , algorithm , biochemistry , physics , quantum mechanics
Assembly of G‐quadruplexes guided by DNA triplexes in a controlled manner is achieved for the first time. The folding of triplex sequences in acidic conditions brings two separated guanine‐rich sequences together and subsequently a G‐quadruplex structure is formed in the presence of K + . Based on this novel platform, label‐free fluorescent logic gates, such as AND, INHIBIT, and NOR, are constructed with ions as input and the fluorescence of a G‐quadruplex‐specific fluorescent probe NMM as output.