DNA Triplexes‐Guided Assembly of G‐Quadruplexes for Constructing Label‐free Fluorescent Logic Gates | Zendy

Xu Lijun | Zendy; Hong Shanni | Zendy; Shen Xiaoqiang | Zendy; Zhou Lu | Zendy; Wang Jine | Zendy; Zhang Jianye | Zendy; Pei Renjun | Zendy

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DNA Triplexes‐Guided Assembly of G‐Quadruplexes for Constructing Label‐free Fluorescent Logic Gates

Author(s) -

Xu Lijun,

Hong Shanni,

Shen Xiaoqiang,

Zhou Lu,

Wang Jine,

Zhang Jianye,

Pei Renjun

Publication year - 2016

Publication title -

chemistry – an asian journal

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.18

H-Index - 106

eISSN - 1861-471X

pISSN - 1861-4728

DOI - 10.1002/asia.201600626

Subject(s) - fluorescence , dna , computer science , logic gate , g quadruplex , chemistry , computational biology , combinatorial chemistry , biology , algorithm , biochemistry , physics , quantum mechanics

Assembly of G‐quadruplexes guided by DNA triplexes in a controlled manner is achieved for the first time. The folding of triplex sequences in acidic conditions brings two separated guanine‐rich sequences together and subsequently a G‐quadruplex structure is formed in the presence of K + . Based on this novel platform, label‐free fluorescent logic gates, such as AND, INHIBIT, and NOR, are constructed with ions as input and the fluorescence of a G‐quadruplex‐specific fluorescent probe NMM as output.

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