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Copper‐Mediated Aromatic 1,1‐Difluoroethylation with (1,1‐Difluoroethyl)trimethylsilane (TMSCF 2 CH 3 )
Author(s) -
Li Xinjin,
Zhao Jingwei,
Wang Yunze,
Rong Jian,
Hu Mingyou,
Chen Dingben,
Xiao Pan,
Ni Chuanfa,
Wang Limin,
Hu Jinbo
Publication year - 2016
Publication title -
chemistry – an asian journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.18
H-Index - 106
eISSN - 1861-471X
pISSN - 1861-4728
DOI - 10.1002/asia.201600577
Subject(s) - trimethylsilane , copper , molecule , chemistry , range (aeronautics) , group (periodic table) , functional group , combinatorial chemistry , medicinal chemistry , organic chemistry , materials science , composite material , polymer
A new method for the formation of 1,1‐difluoroethyl copper species (“CuCF 2 CH 3 ”) with 1,1‐difluoroethylsilane (TMSCF 2 CH 3 ) has been developed. The “CuCF 2 CH 3 ” species can be applied to the efficient 1,1‐difluoroethylation of diaryliodonium salts under mild conditions, affording (1,1‐difluoroethyl)arenes in good to excellent yields. This convenient procedure tolerates a wide range of functional groups and thus serves as a practical synthetic tool for the introduction of CF 2 CH 3 group(s) into complex molecules.