Copper‐Mediated Aromatic 1,1‐Difluoroethylation with (1,1‐Difluoroethyl)trimethylsilane (TMSCF 2 CH 3 ) | Zendy

Li Xinjin | Zendy; Zhao Jingwei | Zendy; Wang Yunze | Zendy; Rong Jian | Zendy; Hu Mingyou | Zendy; Chen Dingben | Zendy; Xiao Pan | Zendy; Ni Chuanfa | Zendy; Wang Limin | Zendy; Hu Jinbo | Zendy

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Copper‐Mediated Aromatic 1,1‐Difluoroethylation with (1,1‐Difluoroethyl)trimethylsilane (TMSCF 2 CH 3 )

Author(s) -

Li Xinjin,

Zhao Jingwei,

Wang Yunze,

Rong Jian,

Hu Mingyou,

Chen Dingben,

Xiao Pan,

Ni Chuanfa,

Wang Limin,

Hu Jinbo

Publication year - 2016

Publication title -

chemistry – an asian journal

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.18

H-Index - 106

eISSN - 1861-471X

pISSN - 1861-4728

DOI - 10.1002/asia.201600577

Subject(s) - trimethylsilane , copper , molecule , chemistry , range (aeronautics) , group (periodic table) , functional group , combinatorial chemistry , medicinal chemistry , organic chemistry , materials science , composite material , polymer

A new method for the formation of 1,1‐difluoroethyl copper species (“CuCF 2 CH 3 ”) with 1,1‐difluoroethylsilane (TMSCF 2 CH 3 ) has been developed. The “CuCF 2 CH 3 ” species can be applied to the efficient 1,1‐difluoroethylation of diaryliodonium salts under mild conditions, affording (1,1‐difluoroethyl)arenes in good to excellent yields. This convenient procedure tolerates a wide range of functional groups and thus serves as a practical synthetic tool for the introduction of CF 2 CH 3 group(s) into complex molecules.

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