Premium
Inside Cover: Asymmetric Total Synthesis of Propindilactone G, Part 1: Initial Attempts towards the Synthesis of Schiartanes (Chem. Asian J. 9/2016)
Author(s) -
Xu LingMing,
You Lin,
Shan ZhenHua,
Yu RuoCheng,
Zhang Bo,
Li YuanHe,
Shi Ying,
Chen JiaHua,
Yang Zhen
Publication year - 2016
Publication title -
chemistry – an asian journal
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.18
H-Index - 106
eISSN - 1861-471X
pISSN - 1861-4728
DOI - 10.1002/asia.201600537
Subject(s) - hydrogenolysis , total synthesis , chemistry , schisandra , stereochemistry , catalysis , organic chemistry , traditional chinese medicine , pathology , medicine , alternative medicine
A concise total synthesis of (+)‐propindilactone G , a nortriterpenoid isolated from the stems of Schisandra propinqua var . propinqua , has been achieved for the first time. The key steps include an asymmetric Diels–Alder reaction, a Pauson–Khand reaction, a Pd‐catalyzed reductive hydrogenolysis reaction, and an oxidative heterocoupling reaction. These reactions enabled the synthesis in only 20 steps. As a consequence of our synthetic studies, the structure of propindilactone G has been revised. More information can be found in their Full Papers on pages 1406, 1414, and 1425 by Zhen Yang and Jia‐Hua Chen et al. in Issue 9, 2016 (DOI: 10.1002/asia.201600129, 10.1002/asia.201600130, 10.1002/asia.201600131.).
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom