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Brønsted Acid‐Catalyzed Synthesis of N ‐Arylindoles from 2‐Vinylanilines and Quinones
Author(s) -
Zhang HanMing,
Gao ZhongHua,
Yi Liang,
Ye Song
Publication year - 2016
Publication title -
chemistry – an asian journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.18
H-Index - 106
eISSN - 1861-471X
pISSN - 1861-4728
DOI - 10.1002/asia.201600420
Subject(s) - intramolecular force , brønsted–lowry acid–base theory , electrophile , catalysis , chemistry , quinone , terminal (telecommunication) , medicinal chemistry , double bond , stereochemistry , organic chemistry , computer science , telecommunications
In the presence of a quinone, Brønsted acid‐catalyzed intramolecular C−N bond formation of o ‐vinylanilines by electrophilic cyclization was developed, giving the corresponding N ‐arylindoles in good to high yields. The reaction worked well for o ‐vinylanilines with terminal and internal C=C double bonds.