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Bioinspired Total Syntheses of Isospongian‐type Diterpenoids (−)‐Kravanhins A and C
Author(s) -
Zhong Zhuliang,
Zhao Gaoyuan,
Xu Dengyu,
Dong Baobiao,
Song Dengpeng,
Xie Xingang,
She Xuegong
Publication year - 2016
Publication title -
chemistry – an asian journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.18
H-Index - 106
eISSN - 1861-471X
pISSN - 1861-4728
DOI - 10.1002/asia.201600398
Subject(s) - aldol reaction , labdane , terpenoid , total synthesis , diterpene , derivative (finance) , chemistry , stereochemistry , organic chemistry , catalysis , financial economics , economics
The first bioinspired total syntheses of (−) kravanhins A and C were accomplished from a labdane diterpenoid derivative. The key reactions involve a photooxidation and a one‐pot sequential aldol cyclization and lactonization, which provide a new plausible biosynthetic pathway for the kravanhins and other symbiotic members.