Organocatalytic Enantioselective Synthesis of Pyrazoles Bearing a Quaternary Stereocenter | Zendy

Vila Carlos | Zendy; Amr Fares Ibrahim | Zendy; Blay Gonzalo | Zendy; Muñoz M. Carmen | Zendy; Pedro José R. | Zendy

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Organocatalytic Enantioselective Synthesis of Pyrazoles Bearing a Quaternary Stereocenter

Author(s) -

Vila Carlos,

Amr Fares Ibrahim,

Blay Gonzalo,

Muñoz M. Carmen,

Pedro José R.

Publication year - 2016

Publication title -

chemistry – an asian journal

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.18

H-Index - 106

eISSN - 1861-471X

pISSN - 1861-4728

DOI - 10.1002/asia.201600325

Subject(s) - stereocenter , enantioselective synthesis , pyrazolones , thiourea , chemistry , isatin , stereochemistry , organic chemistry , catalysis

An efficient one‐pot asymmetric synthesis of pyrazoles bearing a chiral quaternary stereocenter has been developed. Quinine‐derived thiourea catalyzed the enantioselective addition of pyrazolones to isatin‐derived ketimines, providing the corresponding acetylated pyrazoles after in situ treatment with Ac 2 O/Et 3 N. The corresponding pyrazoles were afforded in high yields and excellent enantioselectivities.

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