Nickel‐Catalyzed Oxidative C−H/N−H Isocyanide Insertion: An Efficient Synthesis of Iminoisoindolinone Derivatives

Transition metal‐catalyzed isocyanide insertion has served as a fundamental and important chemical transformation. Classical isocyanide insertion usually occurs between organohalides and nucleophiles, which normally involves tedious and non‐atom‐economical prefunctionalization processes. However, oxidative C−H/N−H isocyanide insertion offers an efficient and green alternative. Herein, a nickel‐catayzed oxidative C−H/N−H isocyanide insertion of aminoquinoline benzamides has been developed. Different kinds of iminoisoindolinone derivatives could be synthesized in good yields by utilizing Ni(acac) 2 as the catalyst. In this transformation, isocyanide serves as an efficient C1 connector, which further inserted into two simple nucleophiles (C−H/N−H), representing an effective way to construct heterocycles.