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Cover Picture: An Enantioselective Assembly of Dihydropyranones through an NHC/LiCl‐Mediated in situ Activation of α,β‐Unsaturated Carboxylic Acids (Chem. Asian J. 5/2016)
Author(s) -
Que Yonglei,
Lu Yinan,
Wang Wenjing,
Wang Yuhong,
Wang Haotian,
Yu Chenxia,
Li Tuanjie,
Wang XiangShan,
Shen Shide,
Yao Changsheng
Publication year - 2016
Publication title -
chemistry – an asian journal
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.18
H-Index - 106
eISSN - 1861-471X
pISSN - 1861-4728
DOI - 10.1002/asia.201600174
Subject(s) - enantioselective synthesis , in situ , cover (algebra) , chemistry , stereochemistry , organic chemistry , catalysis , engineering , mechanical engineering
An efficient assembly of dihydropyranone was realized via the in situ activation of α,β‐unsaturated carboxylic acid and the subsequent formal [3+3] reaction with 1,3‐dicarbonyl compound synergistically mediated by N‐heterocyclic carbene and LiCl. The ready availability and high stability of the starting materials, good yields, and excellent enantioselectivity make this protocol greatly attractive in the chemistry community. More information can be found in the Communication by Changsheng Yao et al. on page 678 in Issue 5, 2016 (DOI: 10.1002/asia.201501353).