Asymmetric P−C Bond Formation: Diastereoselective Synthesis of Adjacent P,C‐Stereogenic Allylic Phosphorus Compounds | Zendy

Xie Peizhong | Zendy; Guo Lei | Zendy; Xu Lanlan | Zendy; Loh TeckPeng | Zendy

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Asymmetric P−C Bond Formation: Diastereoselective Synthesis of Adjacent P,C‐Stereogenic Allylic Phosphorus Compounds

Author(s) -

Xie Peizhong,

Guo Lei,

Xu Lanlan,

Loh TeckPeng

Publication year - 2016

Publication title -

chemistry – an asian journal

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.18

H-Index - 106

eISSN - 1861-471X

pISSN - 1861-4728

DOI - 10.1002/asia.201600108

Subject(s) - stereocenter , allylic rearrangement , phosphine oxide , kinetic resolution , phosphorus , chemistry , enantioselective synthesis , phosphine , catalysis , stereochemistry , medicinal chemistry , organic chemistry

A novel catalytic asymmetric P−C bond formation between phosphinates/phosphine oxide and allylic carbonates was developed. This methodology could not only afford a variety of functionalized adjacent P,C‐stereogenic phosphorus compounds in high yields with high regio‐ and diastereoselectivities but also provide an alternative strategy to access enantiomerically enriched ( S P )‐phosphinates through kinetic resolution.

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