Premium
Asymmetric P−C Bond Formation: Diastereoselective Synthesis of Adjacent P,C‐Stereogenic Allylic Phosphorus Compounds
Author(s) -
Xie Peizhong,
Guo Lei,
Xu Lanlan,
Loh TeckPeng
Publication year - 2016
Publication title -
chemistry – an asian journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.18
H-Index - 106
eISSN - 1861-471X
pISSN - 1861-4728
DOI - 10.1002/asia.201600108
Subject(s) - stereocenter , allylic rearrangement , phosphine oxide , kinetic resolution , phosphorus , chemistry , enantioselective synthesis , phosphine , catalysis , stereochemistry , medicinal chemistry , organic chemistry
A novel catalytic asymmetric P−C bond formation between phosphinates/phosphine oxide and allylic carbonates was developed. This methodology could not only afford a variety of functionalized adjacent P,C‐stereogenic phosphorus compounds in high yields with high regio‐ and diastereoselectivities but also provide an alternative strategy to access enantiomerically enriched ( S P )‐phosphinates through kinetic resolution.