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One‐Pot Synthesis of Polysubstituted Benzenes through a N , N ‐dimethyl‐4‐aminopyridine (DMAP)‐Catalyzed [4+2] Benzannulation of 1,3‐Bis(sulfonyl)butadienes and γ‐Substituted Allenoates
Author(s) -
Chang Meijia,
Wu Chengzhou,
Zheng Jie,
Huang You
Publication year - 2016
Publication title -
chemistry – an asian journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.18
H-Index - 106
eISSN - 1861-471X
pISSN - 1861-4728
DOI - 10.1002/asia.201600102
Subject(s) - sulfonyl , regioselectivity , catalysis , 2 aminopyridine , chemistry , annulation , medicinal chemistry , organic chemistry , combinatorial chemistry , alkyl
A new strategy for the one‐pot synthesis of polysubstituted benzenes through a N , N ‐dimethyl‐4‐aminopyridine (DMAP)‐catalyzed [4+2] benzannulation from readily prepared 1,3‐bis(sulfonyl)butadienes and γ‐substituted allenoates is described. This method provides a facile, metal‐free and general route to highly substituted benzenes under mild conditions in moderate‐to‐good yields with complete regioselectivity.