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Back Cover: Gold‐Catalyzed Intramolecular Tandem Cyclization of Indole‐Ynamides: Diastereoselective Synthesis of Spirocyclic Pyrrolidinoindolines (Chem. Asian J. 3/2016)
Author(s) -
Zheng Nan,
Chang YuanYuan,
Zhang LiJie,
Gong JianXian,
Yang Zhen
Publication year - 2016
Publication title -
chemistry – an asian journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.18
H-Index - 106
eISSN - 1861-471X
pISSN - 1861-4728
DOI - 10.1002/asia.201600053
Subject(s) - intramolecular force , indole test , chemistry , tandem , combinatorial chemistry , stereochemistry , catalysis , organic chemistry , materials science , composite material
Spirocyclic pyrrolidinoindolines are privileged scaffolds present in a growing number of alkaloids with potential biological importance. A concise and efficient construction of a tetracyclic spirocyclic pyrrolidinoindoline via gold‐catalyzed intramolecular tandem cyclization of indole‐ynamide in a single step is reported. Meanwhile, the corresponding tricyclic spirocyclic pyrrolidinoindoline enone was generated in one pot through a key 1,5‐hydride shift. This method provides a straightforward entry to structurally diverse polycylic pyrrolidinoindoline alkaloids. More information can be found in the Communication by Jian‐Xian Gong, Zhen Yang et al. on page 371 in Issue 3, 2016 (DOI: 10.1002/asia.201500865).