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Inside Cover: Chiral Ammonium Betaine‐Catalyzed Highly Stereoselective Aza‐Henry Reaction of α‐Aryl Nitromethanes with Aromatic N ‐Boc Imines (Chem. Asian J. 2/2015)
Author(s) -
Uraguchi Daisuke,
Oyaizu Keigo,
Noguchi Haruhiro,
Ooi Takashi
Publication year - 2015
Publication title -
chemistry – an asian journal
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.18
H-Index - 106
eISSN - 1861-471X
pISSN - 1861-4728
DOI - 10.1002/asia.201590001
Subject(s) - stereoselectivity , organocatalysis , catalysis , chemistry , aryl , betaine , enantioselective synthesis , combinatorial chemistry , organic chemistry , stereochemistry , alkyl
Organocatalysis Chiral 1,2‐diarylethylenediamine skeletons constitute the core structures of various therapeutic agents and chiral catalysts/ligands. However, methods for their asymmetric synthesis have been extremely limited. In their Communication on page 334 ff. , featured on the Inside Cover, Takashi Ooi et al. report a simple and broadly useful protocol for rapid access to structurally diverse anti ‐1,2‐diarylethylenediamine derivatives, which is based on the highly stereoselective aza‐Henry reaction of α‐aryl nitromethanes and N ‐Boc arylaldimines catalyzed by C 1 ‐symmetric chiral ammonium betaine.