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Cover Picture: Sequential S N Ar Reaction/Suzuki–Miyaura Coupling/C−H Direct Arylations Approach for the Rapid Synthesis of Tetraaryl‐Substituted Pyrazoles (Chem. Asian J. 8/2015)
Author(s) -
Morita Taiki,
Kobayashi Daisuke,
Matsumura Keisuke,
Johmoto Kohei,
Uekusa Hidehiro,
Fuse Shinichiro,
Takahashi Takashi
Publication year - 2015
Publication title -
chemistry – an asian journal
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.18
H-Index - 106
eISSN - 1861-471X
pISSN - 1861-4728
DOI - 10.1002/asia.201580801
Subject(s) - cover (algebra) , chemistry , coupling reaction , combinatorial chemistry , coupling (piping) , medicinal chemistry , catalysis , organic chemistry , materials science , engineering , metallurgy , mechanical engineering
Multiaryl‐substituted pyrazoles are frequently found in pharmaceutical drugs and functional materials. In their Full Paper on page 1626, Shinichiro Fuse et al. report the rapid synthesis of 1,3,4,5‐tetraaryl‐substituted pyrazoles via S N Ar reaction/Suzuki–Miyaura coupling/sequential direct arylations based on a 3‐iodo 1H‐pyrazole scaffold. Structurally diverse pyrazoles with four different aryl rings were obtained in high regioselectivity. This is the first example for the synthesis of pyrazoles with four different aryl groups via four sequential cross‐couplings.