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Inside Cover: Aquation Is a Crucial Activation Step for Anticancer Action of Ruthenium(II) Polypyridyl Complexes to Trigger Cancer Cell Apoptosis (Chem. Asian J. 2/2016)
Author(s) -
Li Meng,
Lai Lanhai,
Zhao Zhennan,
Chen Tianfeng
Publication year - 2016
Publication title -
chemistry – an asian journal
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.18
H-Index - 106
eISSN - 1861-471X
pISSN - 1861-4728
DOI - 10.1002/asia.201501451
Subject(s) - ruthenium , aquation , apoptosis , chemistry , combinatorial chemistry , cancer , cancer research , cancer cell , rational design , nanotechnology , biochemistry , materials science , catalysis , medicine , kinetics , physics , quantum mechanics , reaction rate constant
Ruthenium complexes have emerged as part of new approaches to cancer therapy and have showed extremely promising results in the development of novel metal anticancer drugs. This study demonstrates that aquation is a crucial activation step for anticancer action of ruthenium(II) polypyridyl complexes to trigger cancer cell apoptosis. The results could provide useful information for fine‐tuning the rational design of next‐generation metal medicines. More information can be found in the Full Paper by Tianfeng Chen et al. on page 310 in Issue 2, 2016 (DOI: 10.1002/asia.201501048).