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Palladium‐Catalyzed Site‐Selective C−H Functionalization of Weakly Coordinating Sulfonamides: Synthesis of Biaryl Sulfonamides
Author(s) -
Vanjari Rajeshwer,
Guntreddi Tirumaleswararao,
Singh Krishnd
Publication year - 2016
Publication title -
chemistry – an asian journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.18
H-Index - 106
eISSN - 1861-471X
pISSN - 1861-4728
DOI - 10.1002/asia.201501385
Subject(s) - palladium , surface modification , catalysis , sulfonamide , chemistry , regioselectivity , aryl , combinatorial chemistry , medicinal chemistry , organic chemistry , alkyl
A novel and site selective C−H functionalization of unsubstituted sulfonamides has been developed for the synthesis of ortho aryl sulfonamides. The reaction involves highly regioselective ortho mono arylation of weakly coordinating SO 2 NH 2 directing group by means of aryl iodides. Palladium acetate in the presence of silver(I) oxide is found to be the most effective catalytic system.