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An Enantioselective Assembly of Dihydropyranones through an NHC/LiCl‐Mediated in situ Activation of α,β‐Unsaturated Carboxylic Acids
Author(s) -
Que Yonglei,
Lu Yinan,
Wang Wenjing,
Wang Yuhong,
Wang Haotian,
Yu Chenxia,
Li Tuanjie,
Wang XiangShan,
Shen Shide,
Yao Changsheng
Publication year - 2016
Publication title -
chemistry – an asian journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.18
H-Index - 106
eISSN - 1861-471X
pISSN - 1861-4728
DOI - 10.1002/asia.201501353
Subject(s) - enantioselective synthesis , in situ , chemistry , stereochemistry , organic chemistry , catalysis
A straightforward N ‐heterocyclic carbene (NHC)/LiCl‐mediated synthesis of dihydropyranones from α,β‐unsaturated carboxylic acids and 1,3‐dicarbonyl compounds was realized through the in situ activation strategy. The key advantages of this protocol include ready availability and high stability of starting materials, good yields, and excellent enantioselectivity.