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An Approach for the Selective Detection of Nitric Oxide in Biological Systems: An in vitro and in vivo Perspective
Author(s) -
Gupta Neha,
Imam Reja Shahi,
Bhalla Vandana,
Gupta Muskan,
Kaur Gurcharan,
Kumar Manoj
Publication year - 2016
Publication title -
chemistry – an asian journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.18
H-Index - 106
eISSN - 1861-471X
pISSN - 1861-4728
DOI - 10.1002/asia.201501333
Subject(s) - nitric oxide , in vivo , endogeny , in vitro , nmda receptor , hippocampus , chemistry , fluorescence , biophysics , biochemistry , microbiology and biotechnology , pharmacology , neuroscience , biology , receptor , organic chemistry , physics , quantum mechanics
Abstract A naphthalimide‐based fluorescent probe, LyNP‐NO , was designed and synthesized for the selective detection of exogenously and endogenously generated nitric oxide (NO) in C6 glial cells. In addition, LyNP‐NO was also explored for monitoring endogenous NO levels in rat hippocampus at various tissue depths by stimulating the brain with N ‐methyl‐ d ‐aspartate (NMDA).