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Anticancer Potencies of Pt II ‐ and Pd II ‐linked M 2 L 4 Coordination Capsules with Improved Selectivity
Author(s) -
Ahmedova Anife,
Momekova Denitsa,
Yamashina Masahiro,
Shestakova Pavletta,
Momekov Georgi,
Akita Munetaka,
Yoshizawa Michito
Publication year - 2016
Publication title -
chemistry – an asian journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.18
H-Index - 106
eISSN - 1861-471X
pISSN - 1861-4728
DOI - 10.1002/asia.201501238
Subject(s) - cisplatin , chemistry , toxicity , selectivity , molecule , cytotoxicity , stereochemistry , cytotoxic t cell , coordination complex , metal , in vitro , biochemistry , chemotherapy , biology , organic chemistry , genetics , catalysis
Pt II ‐ and Pd II ‐linked M 2 L 4 coordination capsules, providing a confined cavity encircled by polyaromatic frameworks, exhibit anticancer activities superior to cisplatin against two types of leukemic cells (HL‐60 and SKW‐3) and pronounced toxicity against cisplatin‐resistant cells (HL‐60/CDDP). Notably, the cytotoxic selectivities of the Pt II and Pd II capsules toward cancerous cells are up to 5.3‐fold higher than that of cisplatin, as estimated through the non‐malignant/malignant‐cells toxicity ratio employing normal kidney cells (HEK‐293). In addition, the anticancer activity of the coordination capsules can be easily altered upon encapsulation of organic guest molecules.